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磷脂聚乙二醇氨基(2000)DSPE-PEG-Amine, MW 2,000
1,2-二硬脂酰-sn-丙三基-3-磷酸乙醇胺-N-[氨基(聚乙二醇)-2000 (铵盐)
DSPE-PEG-Amine, MW 2,000
  • 产品编号: BP-22722

  • 相关CAS号:474922-26-4

  • 分子式:474922-26-4

  • 分子量:

订货号 规格 价格 库存 数量 购买
BP-22722 500mg ¥ 9000.00元 1

氨基PEG磷脂(DSPE-PEG-Amine)是异双功能PEG衍生物之一,DSPE(1,2-二硬脂酰基-sn-甘油-3-磷酸乙醇胺) 是一种常用于脂质体合成的饱和18C磷脂。聚乙二醇(PEG)共轭DSPE具有亲水性和疏水性,可用于药物递送,基因转染和生物分子修饰。磷脂的聚乙二醇化显着改善了血液循环时间和胶囊化药物的稳定性。胺官能化的DSPE PEG可通过其反应性氨基进一步修饰PEG脂质。

DSPE-PEG-Amine, MW 2,000 is a PEG polymer containing DSPE and amine end groups. The DSPE-PEGs have been FDA approved for medical applications. The hydrophobic properties of the DSPE allow for the encapsulation and congregation of other hydrophobic drugs. The hydrophilic PEG increases the water solubility of the overall compound allowing for the delivery of the drug. The amine group can react with activated NHS ester to form a stable amide bond. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

一、产品描述
1、名称
      中文:磷脂-聚乙二醇-氨基
       英文:DSPE-PEG-amine
2、CAS:474922-26-4
3、分子量:2000,PEG分子量可选可定制
4、用 途:仅供科研实验使用
5、溶解性:溶于水和缓冲液、二氯甲烷、氯仿、DMF、DMSO,较少溶于醇、甲苯,不溶于乙醚。
6、外观:白色蜡状
7、储藏条件:-20℃长期保存,干燥
8、质量控制:95%+
9、取用:现配现用,封口膜封口,拧紧瓶盖装入自封袋,及时放入冰箱。

二、产品结构式


BP-22722-结构

三、产品应用

1、制备胺功能化囊泡

2、制备小单室囊泡

3、制备脂质体

1. Stabilization and immobilization of aquaporin reconstituted lipid vesicles for water purification. Sun G, et al. Colloids and Surfaces. B, Biointerfaces, 102, 466-471 (2013)

2. Strategy to enhance lung cancer treatment by five essential elements: inhalation delivery, nanotechnology, tumor-receptor targeting, chemo- and gene therapy. Olga B Garbuzenko et al. Theranostics, 9(26), 8362-8376 (2019-11-23)

3. Landscape phage fusion protein-mediated targeting of nanomedicines enhances their prostate tumor cell association and cytotoxic efficiency. Jayanna PK, et al. Nanomedicine: Nanotechnology, Biology, and Medicine, 6(4), 538-546 (2010)

4. Dual inhibition of CSF1R and MAPK pathways using supramolecular nanoparticles enhances macrophage immunotherapy. Anujan Ramesh et al. Biomaterials, 227, 119559-119559 (2019-11-02)

5. Combating Glioblastoma by Codelivering the Small-Molecule Inhibitor of STAT3 and STAT3siRNA with α5β1 Integrin Receptor-Selective Liposomes. Venugopal Vangala et al.Molecular pharmaceutics, 17(6), 1859-1874 (2020-04-29)

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